eF-site ID 4jzq-AB PDB Code 4jzq Chain A, B click to enlarge Title Crystal structure of human CLIC1 C24D mutant Classification TRANSPORT PROTEIN Compound Chloride intracellular channel protein 1 Source Homo sapiens (Human) (CLIC1_HUMAN) Sequence A:  QPQVELFVKAGSDGAKIGNDPFSQRLFMVLWLKGVTFNVT TVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFL EAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPA LNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQ RKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFR GVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK B:  QPQVELFVKAGSDGAKIGNDPFSQRLFMVLWLKGVTFNVT TVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFL EAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPA LNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQ RKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFR GVHRYLSNAYAREEFASTCPDDEEIELAYEQVAK Description Functional site 1) chain A residue 26-46 type TRANSMEM sequence FSQRLFMVLWLKGVTFNVTTV description Helical; Note=After insertion into the membrane => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 26-46 type TRANSMEM sequence FSQRLFMVLWLKGVTFNVTTV description Helical; Note=After insertion into the membrane => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 24 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11551966, ECO:0007744|PDB:1K0N source Swiss-Prot : SWS_FT_FI2 4) chain A residue 64 type BINDING sequence L description BINDING => ECO:0000269|PubMed:11551966, ECO:0007744|PDB:1K0N source Swiss-Prot : SWS_FT_FI2 5) chain A residue 77 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11551966, ECO:0007744|PDB:1K0N source Swiss-Prot : SWS_FT_FI2 6) chain B residue 24 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11551966, ECO:0007744|PDB:1K0N source Swiss-Prot : SWS_FT_FI2 7) chain B residue 64 type BINDING sequence L description BINDING => ECO:0000269|PubMed:11551966, ECO:0007744|PDB:1K0N source Swiss-Prot : SWS_FT_FI2 8) chain B residue 77 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11551966, ECO:0007744|PDB:1K0N source Swiss-Prot : SWS_FT_FI2 9) chain A residue 13 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 10) chain A residue 119 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 131 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 12) chain B residue 13 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 13) chain B residue 119 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 14) chain B residue 131 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 24 type MOD_RES sequence D description S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:14613939 source Swiss-Prot : SWS_FT_FI5 16) chain B residue 24 type MOD_RES sequence D description S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:14613939 source Swiss-Prot : SWS_FT_FI5 17) chain A residue 121 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 18) chain A residue 156 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 19) chain A residue 211 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 20) chain B residue 121 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 21) chain B residue 156 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 22) chain B residue 211 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 23) chain A residue 233 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1Q5 source Swiss-Prot : SWS_FT_FI7 24) chain B residue 233 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1Q5 source Swiss-Prot : SWS_FT_FI7

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