eF-site ID 4jy0-B PDB Code 4jy0 Chain B click to enlarge Title Crystal structure of hcv ns5b polymerase in complex with compound 3 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Genome polyprotein Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence B:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVGRKPARLIVFPDL GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRYL FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain B residue 366 type sequence C description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 2) chain B residue 368 type sequence S description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 3) chain B residue 384 type sequence L description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 4) chain B residue 386 type sequence R description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 5) chain B residue 407 type sequence S description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 6) chain B residue 410 type sequence G description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 7) chain B residue 411 type sequence N description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 8) chain B residue 414 type sequence M description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 9) chain B residue 415 type sequence Y description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 10) chain B residue 446 type sequence Q description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 11) chain B residue 447 type sequence I description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 12) chain B residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 13) chain B residue 449 type sequence G description BINDING SITE FOR RESIDUE 1O9 B 601 source : AC2 14) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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