eF-site ID 4jy0-AB
PDB Code 4jy0
Chain A, B

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Title Crystal structure of hcv ns5b polymerase in complex with compound 3
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Genome polyprotein
Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4)
Sequence A:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT
TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA
KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKSEVFCVQPRKPARLIVFPD
LGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFL
VNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCD
LAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGV
LTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVIC
ESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELIT
SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTP
INSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD
CQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINR
VASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRY
LFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS
B:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT
TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA
KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKSEVFCVGRKPARLIVFPDL
GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV
NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL
APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL
TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE
SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS
CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI
NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC
QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV
ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRYL
FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS
Description


Functional site

1) chain A
residue 200
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

2) chain A
residue 366
type
sequence C
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

3) chain A
residue 368
type
sequence S
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

4) chain A
residue 384
type
sequence L
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

5) chain A
residue 386
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

6) chain A
residue 394
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

7) chain A
residue 407
type
sequence S
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

8) chain A
residue 410
type
sequence G
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

9) chain A
residue 414
type
sequence M
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

10) chain A
residue 415
type
sequence Y
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

11) chain A
residue 446
type
sequence Q
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

12) chain A
residue 448
type
sequence Y
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

13) chain A
residue 449
type
sequence G
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

14) chain B
residue 366
type
sequence C
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

15) chain B
residue 368
type
sequence S
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

16) chain B
residue 384
type
sequence L
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

17) chain B
residue 386
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

18) chain B
residue 407
type
sequence S
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

19) chain B
residue 410
type
sequence G
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

20) chain B
residue 411
type
sequence N
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

21) chain B
residue 414
type
sequence M
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

22) chain B
residue 415
type
sequence Y
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

23) chain B
residue 446
type
sequence Q
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

24) chain B
residue 447
type
sequence I
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

25) chain B
residue 448
type
sequence Y
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

26) chain B
residue 449
type
sequence G
description BINDING SITE FOR RESIDUE 1O9 B 601
source : AC2

27) chain A
residue 220
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 318
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 319
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

30) chain B
residue 220
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

31) chain B
residue 318
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 319
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

33) chain A
residue 29
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
source Swiss-Prot : SWS_FT_FI2

34) chain A
residue 42
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
source Swiss-Prot : SWS_FT_FI2

35) chain B
residue 29
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
source Swiss-Prot : SWS_FT_FI2

36) chain B
residue 42
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
source Swiss-Prot : SWS_FT_FI2


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