eF-site ID 4jy0-A PDB Code 4jy0 Chain A click to enlarge Title Crystal structure of hcv ns5b polymerase in complex with compound 3 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Genome polyprotein Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence A:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVQPRKPARLIVFPD LGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFL VNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCD LAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGV LTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVIC ESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELIT SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTP INSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINR VASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRY LFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 2) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 3) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 4) chain A residue 384 type sequence L description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 5) chain A residue 386 type sequence R description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 6) chain A residue 394 type sequence R description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 7) chain A residue 407 type sequence S description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 8) chain A residue 410 type sequence G description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 9) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 10) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 11) chain A residue 446 type sequence Q description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 12) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 13) chain A residue 449 type sequence G description BINDING SITE FOR RESIDUE 1O9 A 601 source : AC1 14) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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