eF-site ID 4jy0-A
PDB Code 4jy0
Chain A

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Title Crystal structure of hcv ns5b polymerase in complex with compound 3
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Genome polyprotein
Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4)
Sequence A:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT
TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA
KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKSEVFCVQPRKPARLIVFPD
LGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFL
VNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCD
LAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGV
LTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVIC
ESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELIT
SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTP
INSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD
CQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINR
VASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRY
LFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS
Description


Functional site

1) chain A
residue 200
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

2) chain A
residue 366
type
sequence C
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

3) chain A
residue 368
type
sequence S
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

4) chain A
residue 384
type
sequence L
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

5) chain A
residue 386
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

6) chain A
residue 394
type
sequence R
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

7) chain A
residue 407
type
sequence S
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

8) chain A
residue 410
type
sequence G
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

9) chain A
residue 414
type
sequence M
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

10) chain A
residue 415
type
sequence Y
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

11) chain A
residue 446
type
sequence Q
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

12) chain A
residue 448
type
sequence Y
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

13) chain A
residue 449
type
sequence G
description BINDING SITE FOR RESIDUE 1O9 A 601
source : AC1

14) chain A
residue 220
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 318
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 319
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P26663
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 29
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 42
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
source Swiss-Prot : SWS_FT_FI2


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