eF-site ID 4jx7-AB PDB Code 4jx7 Chain A, B click to enlarge Title Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase pim-1 Source Homo sapiens (Human) (4JX7) Sequence A:  PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER PDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILL YDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLA LRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS B:  KRRRH Description Functional site 1) chain A residue 44 type sequence L description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 2) chain A residue 65 type sequence A description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 3) chain A residue 121 type sequence E description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 4) chain A residue 122 type sequence R description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 5) chain A residue 123 type sequence P description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 6) chain A residue 126 type sequence V description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 7) chain A residue 128 type sequence D description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 8) chain A residue 174 type sequence L description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 9) chain B residue 6 type sequence R description BINDING SITE FOR RESIDUE 1N6 A 401 source : AC1 10) chain A residue 76 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 44-67 type prosite sequence LGSGGFGSVYSGIRVSDNLPVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK source prosite : PS00107 12) chain A residue 163-175 type prosite sequence VLHRDIKDENILI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI source prosite : PS00108 13) chain A residue 37 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 170 type MOD_RES sequence D description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI3

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