eF-site ID 4jwr-A
PDB Code 4jwr
Chain A

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Title Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid
Classification LIGASE/LIGASE INHIBITOR
Compound E3 ubiquitin-protein ligase Mdm2
Source Homo sapiens (Human) (MDM2_HUMAN)
Sequence A:  IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLG
QYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYTM
IYRNLVVV
Description


Functional site

1) chain A
residue 54
type
sequence L
description BINDING SITE FOR RESIDUE 1MY A 201
source : AC1

2) chain A
residue 93
type
sequence V
description BINDING SITE FOR RESIDUE 1MY A 201
source : AC1

3) chain A
residue 96
type
sequence H
description BINDING SITE FOR RESIDUE 1MY A 201
source : AC1

4) chain A
residue 99
type
sequence I
description BINDING SITE FOR RESIDUE 1MY A 201
source : AC1


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