|
|
eF-site ID
|
4jwr-C |
|
PDB Code
|
4jwr |
|
Chain
|
C |
|
click to enlarge
|
|
|
Title
|
Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid |
|
Classification
|
LIGASE/LIGASE INHIBITOR |
|
Compound
|
E3 ubiquitin-protein ligase Mdm2 |
|
Source
|
Homo sapiens (Human) (MDM2_HUMAN) |
|
|
Sequence
|
C: |
IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLG
QYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYTM
IYRNLVVV
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
54 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE 1MY C 201
|
| source |
: AC3
|
|
|
2)
|
chain |
C |
| residue |
93 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE 1MY C 201
|
| source |
: AC3
|
|
|
3)
|
chain |
C |
| residue |
96 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE 1MY C 201
|
| source |
: AC3
|
|
|
4)
|
chain |
C |
| residue |
99 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE 1MY C 201
|
| source |
: AC3
|
|
|
|