|
|
eF-site ID
|
4jwr-B |
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PDB Code
|
4jwr |
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Chain
|
B |
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click to enlarge
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Title
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Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid |
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Classification
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LIGASE/LIGASE INHIBITOR |
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Compound
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E3 ubiquitin-protein ligase Mdm2 |
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Source
|
Homo sapiens (Human) (MDM2_HUMAN) |
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Sequence
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B: |
IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLG
QYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYTM
IYRNLVVV
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
54 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE 1MY B 201
|
| source |
: AC2
|
|
|
2)
|
chain |
B |
| residue |
93 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE 1MY B 201
|
| source |
: AC2
|
|
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3)
|
chain |
B |
| residue |
96 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE 1MY B 201
|
| source |
: AC2
|
|
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4)
|
chain |
B |
| residue |
99 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE 1MY B 201
|
| source |
: AC2
|
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|
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