|
|
eF-site ID
|
4jvr-E |
|
PDB Code
|
4jvr |
|
Chain
|
E |
|
click to enlarge
|
|
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Title
|
Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide |
|
Classification
|
LIGASE/LIGASE INHIBITOR |
|
Compound
|
E3 ubiquitin-protein ligase Mdm2 |
|
Source
|
Homo sapiens (Human) (MDM2_HUMAN) |
|
|
Sequence
|
E: |
IPASEQETLVRPKPLLLKLLKSVGQKDTYTMKEVLFYLGQ
YIMTKRLYDQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTM
IYRNLVVV
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
54 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
2)
|
chain |
E |
| residue |
58 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
3)
|
chain |
E |
| residue |
61 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
4)
|
chain |
E |
| residue |
62 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
5)
|
chain |
E |
| residue |
86 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
6)
|
chain |
E |
| residue |
96 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
7)
|
chain |
E |
| residue |
99 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
8)
|
chain |
E |
| residue |
100 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE 1MT E 201
|
| source |
: AC3
|
|
|
|