eF-site ID 4jvr-C
PDB Code 4jvr
Chain C

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Title Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Classification LIGASE/LIGASE INHIBITOR
Compound E3 ubiquitin-protein ligase Mdm2
Source Homo sapiens (Human) (MDM2_HUMAN)
Sequence C:  QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL
GQYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYT
MIYRNLVVV
Description


Functional site

1) chain C
residue 54
type
sequence L
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

2) chain C
residue 57
type
sequence L
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

3) chain C
residue 61
type
sequence I
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

4) chain C
residue 62
type
sequence M
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

5) chain C
residue 67
type
sequence Y
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

6) chain C
residue 93
type
sequence V
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

7) chain C
residue 96
type
sequence H
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

8) chain C
residue 99
type
sequence I
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2

9) chain C
residue 100
type
sequence Y
description BINDING SITE FOR RESIDUE 1MT C 201
source : AC2


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