eF-site ID 4jvr-ACE PDB Code 4jvr Chain A, C, E click to enlarge Title Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide Classification LIGASE/LIGASE INHIBITOR Compound E3 ubiquitin-protein ligase Mdm2 Source Homo sapiens (Human) (MDM2_HUMAN) Sequence A:  QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL GQYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYT MIYRNLVVV C:  QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL GQYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYT MIYRNLVVV E:  IPASEQETLVRPKPLLLKLLKSVGQKDTYTMKEVLFYLGQ YIMTKRLYDQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTM IYRNLVVV Description Functional site 1) chain A residue 54 type sequence L description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 2) chain A residue 57 type sequence L description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 3) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 4) chain A residue 62 type sequence M description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 5) chain A residue 67 type sequence Y description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 6) chain A residue 96 type sequence H description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 7) chain A residue 99 type sequence I description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 8) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE 1MT A 201 source : AC1 9) chain C residue 54 type sequence L description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 10) chain C residue 57 type sequence L description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 11) chain C residue 61 type sequence I description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 12) chain C residue 62 type sequence M description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 13) chain C residue 67 type sequence Y description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 14) chain C residue 93 type sequence V description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 15) chain C residue 96 type sequence H description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 16) chain C residue 99 type sequence I description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 17) chain C residue 100 type sequence Y description BINDING SITE FOR RESIDUE 1MT C 201 source : AC2 18) chain E residue 54 type sequence L description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 19) chain E residue 58 type sequence G description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 20) chain E residue 61 type sequence I description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 21) chain E residue 62 type sequence M description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 22) chain E residue 86 type sequence F description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 23) chain E residue 96 type sequence H description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 24) chain E residue 99 type sequence I description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3 25) chain E residue 100 type sequence Y description BINDING SITE FOR RESIDUE 1MT E 201 source : AC3

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