eF-site ID 4jvr-A
PDB Code 4jvr
Chain A

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Title Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Classification LIGASE/LIGASE INHIBITOR
Compound E3 ubiquitin-protein ligase Mdm2
Source Homo sapiens (Human) (MDM2_HUMAN)
Sequence A:  QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL
GQYIMTKRLYDHIVYCSNDLLGDLFGVPSFSVKEHRKIYT
MIYRNLVVV
Description


Functional site

1) chain A
residue 54
type
sequence L
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

2) chain A
residue 57
type
sequence L
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

3) chain A
residue 58
type
sequence G
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

4) chain A
residue 62
type
sequence M
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

5) chain A
residue 67
type
sequence Y
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

6) chain A
residue 96
type
sequence H
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

7) chain A
residue 99
type
sequence I
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1

8) chain A
residue 100
type
sequence Y
description BINDING SITE FOR RESIDUE 1MT A 201
source : AC1


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