eF-site ID 4jse-B PDB Code 4jse Chain B click to enlarge Title Structure of rat neuronal nitric oxide synthase heme domain in complex with 6,6'-(pentane-1,5-diyl)bis(4-methylpyridin-2-amine) Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Nitric oxide synthase, brain Source Rattus norvegicus (Rat) (NOS1_RAT) Sequence B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP SVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNK EIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQV FDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRT DGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICI QQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPI RHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSG WYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWK DQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEY RCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEY QPDPWNTHVWKG Description Functional site 1) chain B residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B A 804 source : AC4 2) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 804 source : AC4 3) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 804 source : AC4 4) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 804 source : AC4 5) chain B residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B A 804 source : AC4 6) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE ZN A 806 source : AC6 7) chain B residue 686 type sequence S description BINDING SITE FOR RESIDUE CL A 808 source : AC8 8) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE CL A 808 source : AC8 9) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 809 source : AC9 10) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 809 source : AC9 11) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 12) chain B residue 414 type sequence R description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 13) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 14) chain B residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 15) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 16) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 17) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 18) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 19) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 20) chain B residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 21) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM B 801 source : BC1 22) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 802 source : BC2 23) chain B residue 336 type sequence M description BINDING SITE FOR RESIDUE H4B B 802 source : BC2 24) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 802 source : BC2 25) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 802 source : BC2 26) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 802 source : BC2 27) chain B residue 323 type sequence E description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 28) chain B residue 573 type sequence E description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 29) chain B residue 578 type sequence E description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 30) chain B residue 699 type sequence R description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 31) chain B residue 704 type sequence F description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 32) chain B residue 705 type sequence E description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 33) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE QJ2 B 803 source : BC3 34) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 804 source : BC4 35) chain B residue 649 type sequence V description BINDING SITE FOR RESIDUE ACT B 804 source : BC4 36) chain B residue 477 type sequence S description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 37) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 38) chain B residue 481 type sequence R description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 39) chain B residue 567 type sequence V description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 40) chain B residue 569 type sequence N description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 41) chain B residue 570 type sequence M description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 42) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 43) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 44) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 45) chain B residue 588 type sequence Y description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 46) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE QJ2 B 805 source : BC5 47) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE ZN B 806 source : BC6 48) chain B residue 600 type sequence D description BINDING SITE FOR RESIDUE ZN B 806 source : BC6 49) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE CL B 807 source : BC7 50) chain B residue 600 type sequence D description BINDING SITE FOR RESIDUE CL B 807 source : BC7 51) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE CL B 808 source : BC8 52) chain B residue 600 type sequence D description BINDING SITE FOR RESIDUE CL B 808 source : BC8 53) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 57) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 58) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 59) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 60) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 61) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 62) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2

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