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|
eF-site ID
|
4jhr-AB |
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PDB Code
|
4jhr |
|
Chain
|
A, B |
|
click to enlarge
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Title
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An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs |
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Classification
|
SIGNALING PROTEIN |
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Compound
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G-protein-signaling modulator 2 |
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Source
|
Mus musculus (Mouse) (GPSM2_MOUSE) |
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Sequence
|
A: |
NFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKG
KSEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLG
NTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLG
NAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLG
NTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLG
NAYTALGNHDQAMHFAEKHLEISREVGDLEVLFPPDEDFF
DILVKCQGSRLDDQRCAPPSAATKGPTVPDEDFFSLILRS
QAKRMDEQRV
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| B: |
NFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKG
KSFEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNL
GNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNL
GNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSL
GNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSL
GNAYTALGNHDQAMHFAEKHLEISREVGDLEVPPDEDFFD
ILVKCQGSRLDDQRCAPPSAATKGPTVPDEDFFSLILRSQ
AKRMDEQRV
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Description
|
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Functional site
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|
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1)
|
chain |
A |
| residue |
601 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5S
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
606 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5S
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
601 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5S
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
606 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5S
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
635 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5Q
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
640 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5Q
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
B |
| residue |
635 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5Q
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
B |
| residue |
640 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22952234, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5Q
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|