eF-site ID 4jan-ABGHIL PDB Code 4jan Chain A, B, G, H, I, L click to enlarge Title crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120 Classification viral protein/immune system Compound ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C Source (4JAN) Sequence A:  QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLS PGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSL RLRSVTAADTAVYFCASLPRGQLVNAYFRNWGRGSLVSVT AASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSG ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKS B:  YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPE VVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEAD YYCQVWDSFSTFVFGSGTQVTVLRQPKANPTVTLFPPSSE ELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVE KTVAPT G:  VSTQLLLNGSLAKEEIVIRSENLTDNAKTIIVHLKESVEI VCTRPGDTRQAHCNISEEKWNKTLQKVSKILQEHFPNKAI KFEPHSGGDLEITTHSFNCRGEFFYCNTTKLFNGTYNSTT ITLPCRIKGNITCKSIITGLLLTRDGGNDDNDTETFRPGG H:  QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLS PGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSL RLRSVTAADTAVYFCASLPRGQLVNAYFRNWGRGSLVSVT AASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSG ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VNHKPSNTKVDKKVEPKS I:  STQLLLNGSLAKEEIVIRSENLTDNAKTIIVHLKESVEIV CTRPGQAHCNISEEKWNKTLQKVSKILQEHFPNKAIKFEP HSGGDLEITTHSFNCRGEFFYCNTTKLFNGTYNSTTITLP CRIKGNITCKSIITGLLLTRDGGNDDNDTETFRPGG L:  YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPE VVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEAD YYCQVWDSFSTFVFGSGTQVTVLRQPKANPTVTLFPPSSE ELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVE KTVAPT Description Functional site 1) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 2) chain L residue 191-197 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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