eF-site ID 4j95-C
PDB Code 4j95
Chain C

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Title Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.
Classification TRANSFERASE
Compound Fibroblast growth factor receptor 2
Source Homo sapiens (Human) (FGFR2_HUMAN)
Sequence C:  LPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDK
PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI
INLLGACTQDGPLYVIVEYASKGNLREYLRARRQMTFKDL
VSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA
DFGLARDINNIDYYKNTTNGRLPVKWMAPEALFDRVYTHQ
SDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMD
KPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTL
T
Description


Functional site

1) chain C
residue 490
type
sequence G
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

2) chain C
residue 491
type
sequence A
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

3) chain C
residue 495
type
sequence V
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

4) chain C
residue 515
type
sequence A
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

5) chain C
residue 517
type
sequence K
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

6) chain C
residue 565
type
sequence E
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

7) chain C
residue 567
type
sequence A
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

8) chain C
residue 630
type
sequence R
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

9) chain C
residue 633
type
sequence L
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

10) chain C
residue 644
type
sequence D
description BINDING SITE FOR RESIDUE ACP C 801
source : AC6

11) chain C
residue 625
type
sequence R
description BINDING SITE FOR RESIDUE SO4 C 802
source : AC7

12) chain C
residue 649
type
sequence R
description BINDING SITE FOR RESIDUE SO4 C 802
source : AC7

13) chain C
residue 657
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 C 802
source : AC7

14) chain C
residue 659
type
sequence N
description BINDING SITE FOR RESIDUE SO4 C 802
source : AC7

15) chain C
residue 660
type
sequence T
description BINDING SITE FOR RESIDUE SO4 C 802
source : AC7

16) chain C
residue 635
type
sequence T
description BINDING SITE FOR RESIDUE SO4 C 803
source : AC8

17) chain C
residue 636
type
sequence E
description BINDING SITE FOR RESIDUE SO4 C 803
source : AC8

18) chain C
residue 637
type
sequence N
description BINDING SITE FOR RESIDUE SO4 C 803
source : AC8

19) chain C
residue 639
type
sequence V
description BINDING SITE FOR RESIDUE SO4 C 803
source : AC8

20) chain C
residue 737
type
sequence R
description BINDING SITE FOR RESIDUE SO4 C 804
source : AC9

21) chain C
residue 626
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208
source Swiss-Prot : SWS_FT_FI1

22) chain C
residue 517
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
source Swiss-Prot : SWS_FT_FI2

23) chain C
residue 565
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
source Swiss-Prot : SWS_FT_FI2

24) chain C
residue 571
type BINDING
sequence N
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
source Swiss-Prot : SWS_FT_FI2

25) chain C
residue 487
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
source Swiss-Prot : SWS_FT_FI2

26) chain C
residue 656
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646
source Swiss-Prot : SWS_FT_FI4

27) chain C
residue 657
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646
source Swiss-Prot : SWS_FT_FI4


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