eF-site ID 4j95-B PDB Code 4j95 Chain B click to enlarge Title Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2. Classification TRANSFERASE Compound Fibroblast growth factor receptor 2 Source Homo sapiens (Human) (FGFR2_HUMAN) Sequence B:  LPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDK PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI INLLGACTQDGPLYVIVEYASKGNLREYLRARRPQMTFKD LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI ADFGLARDINNIDYYKNTTNGRLPVKWMAPEALFDRVYTH QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT LT Description Functional site 1) chain B residue 487 type sequence L description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 2) chain B residue 489 type sequence E description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 3) chain B residue 490 type sequence G description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 4) chain B residue 491 type sequence A description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 5) chain B residue 495 type sequence V description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 6) chain B residue 515 type sequence A description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 7) chain B residue 564 type sequence V description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 8) chain B residue 565 type sequence E description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 9) chain B residue 567 type sequence A description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 10) chain B residue 571 type sequence N description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 11) chain B residue 630 type sequence R description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 12) chain B residue 631 type sequence N description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 13) chain B residue 633 type sequence L description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 14) chain B residue 644 type sequence D description BINDING SITE FOR RESIDUE ACP B 801 source : AC4 15) chain B residue 625 type sequence R description BINDING SITE FOR RESIDUE SO4 B 802 source : AC5 16) chain B residue 649 type sequence R description BINDING SITE FOR RESIDUE SO4 B 802 source : AC5 17) chain B residue 657 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 802 source : AC5 18) chain B residue 660 type sequence T description BINDING SITE FOR RESIDUE SO4 B 802 source : AC5 19) chain B residue 626 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 487 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 517 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 565 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 571 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 656 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 657 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4

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