eF-site ID 4j3n-ABCDEF PDB Code 4j3n Chain A, B, C, D, E, F click to enlarge Title Human Topoisomerase Iibeta in complex with DNA Classification ISOMERASE/DNA Compound DNA topoisomerase 2-beta Source Homo sapiens (Human) (4J3N) Sequence A:  PKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGR DRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQY KKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIH HNWPSLLKHGFLEEFITAKEYFADMERHRILFRYAGPEDD AAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYN DFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKR NDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFV GSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARL LFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGI GTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFK GTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK EQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEK LAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQ DILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFIL EKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEG PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS PSDLWKEDLAAFVEELDKVESQERED B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL LINFIHHNWPSLLKHGFLEEFITPAKEAKEYFADMERHRI LFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR LHGTKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQ RKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMM TIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYI FTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIP MVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPH PMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITEL PVRTWTQVYKEQVLEPMLNPALISDYKEYHTDTTVKFVVK MTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKK YETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQ ARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWK EAQGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDL KRKSPSDLWKEDLAAFVEELDKVESQERED C:  AGCCGAGC D:  TGCAGCTCGGCT E:  AGCCGAGC F:  TGCGCTCGGCT Description Functional site 1) chain A residue 557 type sequence D description BINDING SITE FOR RESIDUE MG A 1301 source : AC1 2) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE MG A 1301 source : AC1 3) chain A residue 867 type sequence N description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 4) chain A residue 868 type sequence G description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 5) chain A residue 722 type sequence F description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 6) chain A residue 726 type sequence D description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 7) chain F residue 16 type sequence C description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 8) chain B residue 557 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC4 9) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MG B 1301 source : AC4 10) chain B residue 795 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC5 11) chain B residue 867 type sequence N description BINDING SITE FOR RESIDUE MG B 1302 source : AC5 12) chain A residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 13) chain A residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 14) chain A residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 15) chain A residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 16) chain B residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 17) chain B residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 18) chain B residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 19) chain B residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 20) chain B residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9 21) chain A residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 26) chain A residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 27) chain A residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 28) chain A residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 29) chain A residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 30) chain A residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 31) chain B residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 32) chain B residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 33) chain B residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 34) chain B residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 35) chain B residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 36) chain B residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 37) chain A residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 38) chain B residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 39) chain A residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 40) chain B residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 41) chain A residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 42) chain B residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 43) chain A residue 475-483 type prosite sequence LTEGDSAKS description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS source prosite : PS00177 44) chain A residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 45) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 46) chain B residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 47) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3

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