eF-site ID 4j3n-A
PDB Code 4j3n
Chain A

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Title Human Topoisomerase Iibeta in complex with DNA
Classification ISOMERASE/DNA
Compound DNA topoisomerase 2-beta
Source Homo sapiens (Human) (4J3N)
Sequence A:  PKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGR
DRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQY
KKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIH
HNWPSLLKHGFLEEFITAKEYFADMERHRILFRYAGPEDD
AAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYN
DFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKR
NDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFV
GSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARL
LFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGI
GTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFK
GTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYK
EQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEK
LAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQ
DILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFIL
EKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKS
PSDLWKEDLAAFVEELDKVESQERED
Description


Functional site

1) chain A
residue 557
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1301
source : AC1

2) chain A
residue 559
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1301
source : AC1

3) chain A
residue 867
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1302
source : AC2

4) chain A
residue 868
type
sequence G
description BINDING SITE FOR RESIDUE MG A 1302
source : AC2

5) chain A
residue 722
type
sequence F
description BINDING SITE FOR RESIDUE MG A 1303
source : AC3

6) chain A
residue 726
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1303
source : AC3

7) chain A
residue 475-483
type prosite
sequence LTEGDSAKS
description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS
source prosite : PS00177

8) chain A
residue 821
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI1

9) chain A
residue 477
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 557
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

11) chain A
residue 559
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401
source Swiss-Prot : SWS_FT_FI3

12) chain A
residue 505
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

13) chain A
residue 508
type SITE
sequence N
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

14) chain A
residue 677
type SITE
sequence R
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

15) chain A
residue 678
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

16) chain A
residue 739
type SITE
sequence K
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

17) chain A
residue 947
type SITE
sequence W
description Interaction with DNA
source Swiss-Prot : SWS_FT_FI4

18) chain A
residue 773
type SITE
sequence Y
description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995
source Swiss-Prot : SWS_FT_FI5

19) chain A
residue 820
type SITE
sequence R
description Transition state stabilizer
source Swiss-Prot : SWS_FT_FI6

20) chain A
residue 872
type SITE
sequence I
description Important for DNA bending; intercalates between base pairs of target DNA
source Swiss-Prot : SWS_FT_FI7

21) chain A
residue 641
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

22) chain A
residue 671
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

23) chain A
residue 707
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8

24) chain A
residue 1087
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI8


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