eF-site ID 4j0u-A
PDB Code 4j0u
Chain A

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Title Crystal structure of IFIT5/ISG58
Classification RNA BINDING PROTEIN
Compound Interferon-induced protein with tetratricopeptide repeats 5
Source Homo sapiens (Human) (IFIT5_HUMAN)
Sequence A:  MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQ
QLEFLKSRLALYNLLAYVKHLKGQNKDALECLEQAEEIIQ
QEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGN
VCKKLSSPSNYKLECPETDCEKGWALLKFGGKYYQKAKAA
FEKALEVEPDNPEFNIGYAITVYRLDDVKSFSLGPLRKAV
TLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQ
PYVLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQ
MGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFK
AAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLE
NITDDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKD
RSPLRTKLTSALKKLSTKRLCHNALDQSLSALGFVYKLEG
EKRQAAEYYEKAQKIDPENAEFLTALCELRL
Description (1)  Interferon-induced protein with tetratricopeptide repeats 5


Functional site

1) chain A
residue 33
type SITE
sequence E
description Interaction with PPP-RNA
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 37
type SITE
sequence T
description Interaction with PPP-RNA
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 41
type SITE
sequence Q
description Interaction with PPP-RNA
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 150
type SITE
sequence K
description Interaction with PPP-RNA
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 186
type SITE
sequence R
description Interaction with PPP-RNA
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 250
type SITE
sequence Y
description Interaction with PPP-RNA
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 288
type SITE
sequence Q
description Interaction with the 5'-triphosphate group of PPP-RNA
source Swiss-Prot : SWS_FT_FI2


Display surface

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