eF-site ID 4j04-B PDB Code 4j04 Chain B click to enlarge Title Crystal structure of hcv ns5b polymerase in complex with 4-CHLORO-2-{[(2,4,5-TRICHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Genome polyprotein Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence B:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVGRKPARLIVFPDL GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRYL FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain B residue 205 type sequence V description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 2) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 3) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 4) chain B residue 360 type sequence L description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 5) chain B residue 361 type sequence E description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 6) chain B residue 370 type sequence V description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 7) chain B residue 372 type sequence V description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 8) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 9) chain B residue 382 type sequence Y description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 10) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC6 11) chain B residue 318 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC7 12) chain B residue 319 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC7 13) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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