eF-site ID 4j04-AB PDB Code 4j04 Chain A, B click to enlarge Title Crystal structure of hcv ns5b polymerase in complex with 4-CHLORO-2-{[(2,4,5-TRICHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Genome polyprotein Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence A:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVQPRKPARLIVFPD LGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFL VNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCD LAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGV LTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVIC ESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELIT SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTP INSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINR VASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRY LFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS B:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVGRKPARLIVFPDL GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRYL FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain A residue 419 type sequence L description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 2) chain A residue 422 type sequence R description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 3) chain A residue 423 type sequence M description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 4) chain A residue 474 type sequence L description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 5) chain A residue 497 type sequence L description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 6) chain A residue 498 type sequence R description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 7) chain A residue 501 type sequence R description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 8) chain A residue 528 type sequence W description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 9) chain A residue 533 type sequence K description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 10) chain A residue 205 type sequence V description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 11) chain A residue 208 type sequence W description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 12) chain A residue 209 type sequence K description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 13) chain A residue 359 type sequence D description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 14) chain A residue 360 type sequence L description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 15) chain A residue 361 type sequence E description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 16) chain A residue 370 type sequence V description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 17) chain A residue 372 type sequence V description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 18) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 19) chain A residue 382 type sequence Y description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 20) chain A residue 359 type sequence D description BINDING SITE FOR RESIDUE MN A 603 source : AC3 21) chain A residue 318 type sequence D description BINDING SITE FOR RESIDUE MN A 604 source : AC4 22) chain A residue 319 type sequence D description BINDING SITE FOR RESIDUE MN A 604 source : AC4 23) chain B residue 205 type sequence V description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 24) chain B residue 208 type sequence W description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 25) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 26) chain B residue 360 type sequence L description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 27) chain B residue 361 type sequence E description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 28) chain B residue 370 type sequence V description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 29) chain B residue 372 type sequence V description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 30) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 31) chain B residue 382 type sequence Y description BINDING SITE FOR RESIDUE 1JF B 601 source : AC5 32) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC6 33) chain B residue 318 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC7 34) chain B residue 319 type sequence D description BINDING SITE FOR RESIDUE MN B 603 source : AC7 35) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1

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