eF-site ID 4j04-A PDB Code 4j04 Chain A click to enlarge Title Crystal structure of hcv ns5b polymerase in complex with 4-CHLORO-2-{[(2,4,5-TRICHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Genome polyprotein Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence A:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVQPRKPARLIVFPD LGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFL VNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCD LAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGV LTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVIC ESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELIT SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTP INSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINR VASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRY LFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain A residue 419 type sequence L description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 2) chain A residue 422 type sequence R description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 3) chain A residue 423 type sequence M description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 4) chain A residue 474 type sequence L description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 5) chain A residue 497 type sequence L description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 6) chain A residue 498 type sequence R description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 7) chain A residue 501 type sequence R description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 8) chain A residue 528 type sequence W description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 9) chain A residue 533 type sequence K description BINDING SITE FOR RESIDUE 1JF A 601 source : AC1 10) chain A residue 205 type sequence V description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 11) chain A residue 208 type sequence W description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 12) chain A residue 209 type sequence K description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 13) chain A residue 359 type sequence D description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 14) chain A residue 360 type sequence L description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 15) chain A residue 361 type sequence E description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 16) chain A residue 370 type sequence V description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 17) chain A residue 372 type sequence V description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 18) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 19) chain A residue 382 type sequence Y description BINDING SITE FOR RESIDUE 1JF A 602 source : AC2 20) chain A residue 359 type sequence D description BINDING SITE FOR RESIDUE MN A 603 source : AC3 21) chain A residue 318 type sequence D description BINDING SITE FOR RESIDUE MN A 604 source : AC4 22) chain A residue 319 type sequence D description BINDING SITE FOR RESIDUE MN A 604 source : AC4 23) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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