eF-site ID 4ium-AB PDB Code 4ium Chain A, B click to enlarge Title Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin Classification HYDROLASE/PROTEIN BINDING Compound papain-like protease 2 Source Equine arteritis virus (strain Bucyrus) (EAV) (UBC_HUMAN) Sequence A:  GYNPPGDGACGYRCLAFMNGATVVSAGCSSDLWCDDELAY RVFQLSPTFTVTIPGGRVCPNAKYAMICDKQHWRVKRAKG VGLCLDESCFRGICNCQRMSGPPPAPVSAAVLDHILEAAT FGNVRVV B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX Description (1)  papain-like protease 2 (E.C.3.4.22.-), Ubiquitin Functional site 1) chain A residue 319 type sequence C description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 2) chain A residue 349 type sequence C description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 3) chain A residue 354 type sequence C description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 4) chain A residue 356 type sequence C description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 5) chain A residue 278 type sequence M description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 6) chain A residue 280 type sequence G description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 7) chain A residue 323 type sequence K description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 8) chain A residue 324 type sequence Y description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 9) chain B residue 32 type sequence D description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 10) chain A residue 313 type sequence I description BINDING SITE FOR RESIDUE GOL B 101 source : AC3 11) chain B residue 7 type sequence T description BINDING SITE FOR RESIDUE GOL B 101 source : AC3 12) chain B residue 8 type sequence L description BINDING SITE FOR RESIDUE GOL B 101 source : AC3 13) chain B residue 36 type sequence I description BINDING SITE FOR RESIDUE GOL B 101 source : AC3 14) chain B residue 69 type sequence L description BINDING SITE FOR RESIDUE GOL B 101 source : AC3 15) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI10 17) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 18) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 19) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 20) chain A residue 349 type SITE sequence C description Essential for function source Swiss-Prot : SWS_FT_FI2 21) chain A residue 354 type SITE sequence C description Essential for function source Swiss-Prot : SWS_FT_FI2 22) chain A residue 356 type SITE sequence C description Essential for function source Swiss-Prot : SWS_FT_FI2 23) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI9 24) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI8 25) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI5 27) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI6 28) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 29) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 30) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

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