eF-site ID 4itx-A PDB Code 4itx Chain A click to enlarge Title P113S mutant of E. coli Cystathionine beta-lyase MetC inhibited by reaction with L-Ala-P Classification LYASE Compound Cystathionine beta-lyase MetC Source Escherichia coli (strain K12) (METC_ECOLI) Sequence A:  KLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKH ATRNRANGELFYGRRGTLTHFSLQQAMCELEGGAGCVLFP CGAAAVANSILAFIEQGDHVLMTNTAYESSQDFCSKILSK LGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVH DVPAIVAAVRSVVPDAIIMIDNTWAAGVLFKALDFGIDVS IQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMV DADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVA RVNHPALPGSKGHEFWKRDFTGSSGLFSFVLKKKLNNEEL ANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRPQGEI DFSGTLIRLHIGLEDVDDLIADLDAGFARIV Description Functional site 1) chain A residue 56 type sequence Y description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 2) chain A residue 58 type sequence R description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 3) chain A residue 85 type sequence C description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 4) chain A residue 86 type sequence G description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 5) chain A residue 87 type sequence A description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 6) chain A residue 111 type sequence Y description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 7) chain A residue 154 type sequence E description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 8) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 9) chain A residue 207 type sequence A description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 10) chain A residue 209 type sequence T description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 11) chain A residue 210 type sequence K description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 12) chain A residue 219 type sequence M description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 13) chain A residue 338 type sequence Y description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 14) chain A residue 339 type sequence S description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 15) chain A residue 340 type sequence W description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 16) chain A residue 372 type sequence R description BINDING SITE FOR RESIDUE IN5 A 401 source : AC1 17) chain A residue 12 type sequence N description BINDING SITE FOR RESIDUE CA A 402 source : AC2 18) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE CA B 402 source : AC4 19) chain A residue 344 type sequence E description BINDING SITE FOR RESIDUE CA B 402 source : AC4 20) chain A residue 210 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:3307782, ECO:0000269|PubMed:8831789 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 202-216 type prosite sequence DVSIQAATKYLVGHS description CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DVsiqAATKYLvGHS source prosite : PS00868 22) chain A residue 58 type catalytic sequence R description 449 source MCSA : MCSA1 23) chain A residue 111 type catalytic sequence Y description 449 source MCSA : MCSA1 24) chain A residue 185 type catalytic sequence D description 449 source MCSA : MCSA1 25) chain A residue 210 type catalytic sequence K description 449 source MCSA : MCSA1

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