eF-site ID 4itg-AB PDB Code 4itg Chain A, B click to enlarge Title P113S mutant of E. coli Cystathionine beta-lyase MetC Classification LYASE Compound Cystathionine beta-lyase MetC Source Escherichia coli (strain K12) (METC_ECOLI) Sequence A:  KLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKH ATRNRANGELFYGRRGTLTHFSLQQAMCELEGGAGCVLFP CGAAAVANSILAFIEQGDHVLMTNTAYESSQDFCSKILSK LGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVH DVPAIVAAVRSVVPDAIIMIDNTWAAGVLFKALDFGIDVS IQAATXYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMV DADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVA RVNHPALPGSKGHEFWKRDFTGSSGLFSFVLKKKLNNEEL ANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRPQGEI DFSGTLIRLHIGLEDVDDLIADLDAGFARIV B:  KKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKK HATRNRANGELFYGRRGTLTHFSLQQAMCELEGGAGCVLF PCGAAAVANSILAFIEQGDHVLMTNTAYESSQDFCSKILS KLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEV HDVPAIVAAVRSVVPDAIIMIDNTWAAGVLFKALDFGIDV SIQAATXYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQM VDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQV ARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLKKKLNNEE LANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRPQGE IDFSGTLIRLHIGLEDVDDLIADLDAGFARIV Description Functional site 1) chain A residue 111 type sequence Y description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 2) chain A residue 113 type sequence S description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 3) chain A residue 116 type sequence D description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 4) chain A residue 210 type sequence X description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 5) chain A residue 338 type sequence Y description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 6) chain A residue 339 type sequence S description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 7) chain A residue 340 type sequence W description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 8) chain A residue 372 type sequence R description BINDING SITE FOR RESIDUE EPE A 401 source : AC1 9) chain B residue 111 type sequence Y description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 10) chain B residue 113 type sequence S description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 11) chain B residue 116 type sequence D description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 12) chain B residue 210 type sequence X description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 13) chain B residue 338 type sequence Y description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 14) chain B residue 339 type sequence S description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 15) chain B residue 340 type sequence W description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 16) chain B residue 372 type sequence R description BINDING SITE FOR RESIDUE EPE B 401 source : AC2 17) chain A residue 58 type catalytic sequence R description 449 source MCSA : MCSA1 18) chain A residue 111 type catalytic sequence Y description 449 source MCSA : MCSA1 19) chain A residue 185 type catalytic sequence D description 449 source MCSA : MCSA1 20) chain A residue 210 type catalytic sequence X description 449 source MCSA : MCSA1 21) chain B residue 58 type catalytic sequence R description 449 source MCSA : MCSA2 22) chain B residue 111 type catalytic sequence Y description 449 source MCSA : MCSA2 23) chain B residue 185 type catalytic sequence D description 449 source MCSA : MCSA2 24) chain B residue 210 type catalytic sequence X description 449 source MCSA : MCSA2 25) chain A residue 202-216 type prosite sequence DVSIQAATXYLVGHS description CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DVsiqAATKYLvGHS source prosite : PS00868 26) chain A residue 210 type MOD_RES sequence X description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:3307782, ECO:0000269|PubMed:8831789 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 210 type MOD_RES sequence X description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:3307782, ECO:0000269|PubMed:8831789 source Swiss-Prot : SWS_FT_FI1

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