eF-site ID 4int-K PDB Code 4int Chain K click to enlarge Title Yeast 20S proteasome in complex with the vinyl sulfone LU122 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component Y7 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence K:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain K residue 1 type sequence T description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 2) chain K residue 20 type sequence A description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 3) chain K residue 21 type sequence T description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 4) chain K residue 31 type sequence V description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 5) chain K residue 45 type sequence M description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 6) chain K residue 47 type sequence G description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 7) chain K residue 49 type sequence A description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 8) chain K residue 53 type sequence Q description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 9) chain K residue 131 type sequence S description BINDING SITE FOR RESIDUE 1G5 K 301 source : AC2 10) chain K residue 4-51 type prosite sequence LAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLG TMAGGAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD source prosite : PS00854 11) chain K residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2

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