|
|
eF-site ID
|
4inr-B |
|
PDB Code
|
4inr |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
Yeast 20S proteasome in complex with the vinyl sulfone LU102 |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Proteasome component Y7 |
|
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
B: |
GSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMAS
DGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLT
ADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQG
YTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWK
AISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTT
DSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVK
TGIT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
35-82 |
| type |
prosite |
| sequence |
IGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAV
AVAGLTAD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD
|
| source |
prosite : PS00854
|
|
|
2)
|
chain |
B |
| residue |
198 |
| type |
ACT_SITE |
| sequence |
K
|
| description |
Nucleophile => ECO:0000269|PubMed:9087403
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
230 |
| type |
ACT_SITE |
| sequence |
K
|
| description |
Nucleophile => ECO:0000269|PubMed:9087403
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
5-27 |
| type |
prosite |
| sequence |
YDSRTTIFSPEGRLYQVEYALES
|
| description |
PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdralSiFSPdGHifQVEYAleA
|
| source |
prosite : PS00388
|
|
|
|