eF-site ID 4ijp-B PDB Code 4ijp Chain B click to enlarge Title Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase PRP4 homolog Source Homo sapiens (Human) (PRP4B_HUMAN) Sequence B:  WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDN ARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDK FHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESK TILKLCDFGSASHVADNDITPXLVSRFYRAPEIIIGKSYD YGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGK MPNKMIRKGVFKDQHFDQNLNFMYIEVDREKVTVMSTINP TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKR ISINQALQHAFIQE Description (1)  Serine/threonine-protein kinase PRP4 homolog (E.C.2.7.11.1) Functional site 1) chain B residue 709 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1102 source : AC2 2) chain B residue 990 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1104 source : AC4 3) chain B residue 693 type sequence T description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 4) chain B residue 701 type sequence V description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 5) chain B residue 703 type sequence R description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 6) chain B residue 715 type sequence A description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 7) chain B residue 717 type sequence K description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 8) chain B residue 770 type sequence L description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 9) chain B residue 771 type sequence S description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 10) chain B residue 772 type sequence M description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 11) chain B residue 776 type sequence E description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 12) chain B residue 822 type sequence L description BINDING SITE FOR RESIDUE 1EH B 1101 source : AC6 13) chain B residue 849 type sequence X description BINDING SITE FOR RESIDUE SO4 B 1102 source : AC7 14) chain B residue 853 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1102 source : AC7 15) chain B residue 856 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1102 source : AC7 16) chain B residue 804 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1103 source : AC8 17) chain B residue 808 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1103 source : AC8 18) chain B residue 852 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q5RKH1 source Swiss-Prot : SWS_FT_FI5 19) chain B residue 815 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 693 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 717 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 717 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 849 type MOD_RES sequence X description Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4

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