|
|
eF-site ID
|
4ibs-C |
|
PDB Code
|
4ibs |
|
Chain
|
C |
|
click to enlarge
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Title
|
Human p53 core domain with hot spot mutation R273H (form I) |
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Classification
|
DNA BINDING PROTEIN |
|
Compound
|
Cellular tumor antigen p53 |
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Source
|
Homo sapiens (Human) (P53_HUMAN) |
|
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Sequence
|
C: |
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFC
QLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRR
CPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHS
VVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTII
TLEDSSGNLLGRNSFEVHVCACPGRDRRTEEENL
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Description
|
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Functional site
|
|
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1)
|
chain |
C |
| residue |
176 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN C 301
|
| source |
: AC3
|
|
|
2)
|
chain |
C |
| residue |
179 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN C 301
|
| source |
: AC3
|
|
|
3)
|
chain |
C |
| residue |
238 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN C 301
|
| source |
: AC3
|
|
|
4)
|
chain |
C |
| residue |
242 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN C 301
|
| source |
: AC3
|
|
|
5)
|
chain |
C |
| residue |
179 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
C |
| residue |
238 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
C |
| residue |
242 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
C |
| residue |
176 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
C |
| residue |
120 |
| type |
SITE |
| sequence |
K
|
| description |
Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
C |
| residue |
120 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
11)
|
chain |
C |
| residue |
183 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
12)
|
chain |
C |
| residue |
269 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
13)
|
chain |
C |
| residue |
284 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|