eF-site ID 4i85-B
PDB Code 4i85
Chain B

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Title Crystal structure of transthyretin in complex with CHF5074 at neutral pH
Classification transport protein/inhibitor
Compound Transthyretin
Source Homo sapiens (Human) (TTHY_HUMAN)
Sequence B:  CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKT
SESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHE
HAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN
Description


Functional site

1) chain B
residue 15
type
sequence K
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

2) chain B
residue 15
type
sequence K
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

3) chain B
residue 17
type
sequence L
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

4) chain B
residue 17
type
sequence L
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

5) chain B
residue 108
type
sequence A
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

6) chain B
residue 110
type
sequence L
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

7) chain B
residue 117
type
sequence S
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

8) chain B
residue 117
type
sequence S
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

9) chain B
residue 118
type
sequence T
description BINDING SITE FOR RESIDUE H50 B 201
source : AC2

10) chain B
residue 42
type MOD_RES
sequence E
description 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012
source Swiss-Prot : SWS_FT_FI3

11) chain B
residue 52
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P02767
source Swiss-Prot : SWS_FT_FI4

12) chain B
residue 98
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329
source Swiss-Prot : SWS_FT_FI5

13) chain B
residue 15
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
source Swiss-Prot : SWS_FT_FI1

14) chain B
residue 54
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
source Swiss-Prot : SWS_FT_FI1

15) chain B
residue 117
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT
source Swiss-Prot : SWS_FT_FI1

16) chain B
residue 10
type MOD_RES
sequence C
description Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E
source Swiss-Prot : SWS_FT_FI2


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