eF-site ID 4i7d-A PDB Code 4i7d Chain A click to enlarge Title Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR Classification LIGASE/LIGASE INHIBITOR Compound E3 ubiquitin-protein ligase SIAH1 Source Homo sapiens (Human) (PHYL_DROME) Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC PGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDI NLPGAVDWVMMQSCFGFHFMLVLEKQEQQFFAIVQLIGTR KQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSD CLVFDTSIAQLFAENGNLGINVTISMC Description Functional site 1) chain A residue 97 type sequence P description BINDING SITE FOR RESIDUE ACE B 112 source : AC1 2) chain A residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN A 601 source : AC3 3) chain A residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN A 601 source : AC3 4) chain A residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN A 601 source : AC3 5) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN A 601 source : AC3 6) chain A residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC4 7) chain A residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC4 8) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN A 602 source : AC4 9) chain A residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC4 10) chain A residue 231 type sequence R description BINDING SITE FOR RESIDUE MPD A 603 source : AC5 11) chain A residue 233 type sequence R description BINDING SITE FOR RESIDUE MPD A 603 source : AC5 12) chain A residue 91 type sequence A description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 13) chain A residue 92 type sequence N description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 14) chain A residue 93 type sequence S description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 15) chain A residue 94 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 16) chain A residue 95 type sequence L description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 17) chain A residue 96 type sequence F description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 18) chain A residue 97 type sequence P description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 19) chain A residue 108 type sequence T description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 20) chain A residue 130 type sequence C description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 21) chain A residue 158 type sequence L description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 22) chain A residue 162 type sequence D description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 23) chain A residue 163 type sequence I description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 24) chain A residue 164 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 25) chain A residue 165 type sequence F description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 26) chain A residue 166 type sequence L description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 27) chain A residue 168 type sequence T description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 28) chain A residue 172 type sequence L description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 29) chain A residue 176 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 30) chain A residue 177 type sequence D description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 31) chain A residue 178 type sequence W description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 32) chain A residue 179 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 33) chain A residue 180 type sequence M description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 34) chain A residue 194 type sequence E description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 35) chain A residue 224 type sequence R description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 36) chain A residue 277 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 37) chain A residue 278 type sequence T description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC8 38) chain A residue 134 type sequence S description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD source : AC9 39) chain A residue 93-153 type ZN_FING sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG ASCKWQGSLDAVMPHLMHQHK description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 41) chain A residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 42) chain A residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 43) chain A residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 44) chain A residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 45) chain A residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 46) chain A residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 47) chain A residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3

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