eF-site ID 4i7c-C PDB Code 4i7c Chain C click to enlarge Title Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR Classification LIGASE/LIGASE INHIBITOR Compound E3 ubiquitin-protein ligase SIAH1 Source Homo sapiens (Human) (PHYL_DROME) Sequence C:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC PGASCKWQGSLDAVMPHLMHQHKSICTLQGEDIVFLATDI NLPGAVDWVMMQSCFGFHFMLVLEKQEKGHQQFFAIVQLI GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM NSDCLVFDTSIAQLFAENGNLGINVTISMC Description Functional site 1) chain C residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN C 601 source : AC4 2) chain C residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN C 601 source : AC4 3) chain C residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN C 601 source : AC4 4) chain C residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN C 601 source : AC4 5) chain C residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN C 602 source : AC5 6) chain C residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN C 602 source : AC5 7) chain C residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN C 602 source : AC5 8) chain C residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN C 602 source : AC5 9) chain C residue 131 type sequence P description BINDING SITE FOR RESIDUE MPD C 603 source : AC6 10) chain C residue 152 type sequence H description BINDING SITE FOR RESIDUE MPD C 603 source : AC6 11) chain C residue 154 type sequence S description BINDING SITE FOR RESIDUE MPD C 603 source : AC6 12) chain C residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 13) chain C residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 14) chain C residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 15) chain C residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 16) chain C residue 93-153 type ZN_FING sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG ASCKWQGSLDAVMPHLMHQHK description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 18) chain C residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 19) chain C residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 20) chain C residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3

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