eF-site ID 4i7c-ABCD
PDB Code 4i7c
Chain A, B, C, D

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Title Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR
Classification LIGASE/LIGASE INHIBITOR
Compound E3 ubiquitin-protein ligase SIAH1
Source Homo sapiens (Human) (PHYL_DROME)
Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC
PGASCKWQGSLDAVMPHLMHQHKSICTLQGEDIVFLATDI
NLPGAVDWVMMQSCFGFHFMLVLEKQEKQQFFAIVQLIGT
RKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNS
DCLVFDTSIAQLFAENGNLGINVTISMC
B:  KLRPVXMVRPWVR
C:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC
PGASCKWQGSLDAVMPHLMHQHKSICTLQGEDIVFLATDI
NLPGAVDWVMMQSCFGFHFMLVLEKQEKGHQQFFAIVQLI
GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM
NSDCLVFDTSIAQLFAENGNLGINVTISMC
D:  KLRPVXMVRPWVR
Description


Functional site
1) chain A
residue 128
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
2) chain A
residue 135
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
3) chain A
residue 147
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
4) chain A
residue 152
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
5) chain A
residue 98
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
6) chain A
residue 105
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
7) chain A
residue 117
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
8) chain A
residue 121
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
9) chain A
residue 130
type
sequence C
description BINDING SITE FOR RESIDUE MPD A 603
source : AC3
10) chain A
residue 131
type
sequence P
description BINDING SITE FOR RESIDUE MPD A 603
source : AC3
11) chain A
residue 152
type
sequence H
description BINDING SITE FOR RESIDUE MPD A 603
source : AC3
12) chain A
residue 154
type
sequence S
description BINDING SITE FOR RESIDUE MPD A 603
source : AC3
13) chain A
residue 177
type
sequence D
description BINDING SITE FOR RESIDUE MPD A 603
source : AC3
14) chain B
residue 123
type
sequence W
description BINDING SITE FOR RESIDUE MPD A 603
source : AC3
15) chain C
residue 128
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 601
source : AC4
16) chain C
residue 135
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 601
source : AC4
17) chain C
residue 147
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 601
source : AC4
18) chain C
residue 152
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 601
source : AC4
19) chain C
residue 98
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 602
source : AC5
20) chain C
residue 105
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 602
source : AC5
21) chain C
residue 117
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 602
source : AC5
22) chain C
residue 121
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 602
source : AC5
23) chain C
residue 131
type
sequence P
description BINDING SITE FOR RESIDUE MPD C 603
source : AC6
24) chain C
residue 152
type
sequence H
description BINDING SITE FOR RESIDUE MPD C 603
source : AC6
25) chain C
residue 154
type
sequence S
description BINDING SITE FOR RESIDUE MPD C 603
source : AC6
26) chain D
residue 123
type
sequence W
description BINDING SITE FOR RESIDUE MPD C 603
source : AC6
27) chain A
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
28) chain A
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
29) chain A
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
30) chain A
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
31) chain C
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
32) chain C
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
33) chain C
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
34) chain C
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
35) chain A
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
36) chain C
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
37) chain A
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
38) chain A
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
39) chain A
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
40) chain A
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
41) chain C
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
42) chain C
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
43) chain C
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
44) chain C
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3

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