eF-site ID 4i7c-A PDB Code 4i7c Chain A click to enlarge Title Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR Classification LIGASE/LIGASE INHIBITOR Compound E3 ubiquitin-protein ligase SIAH1 Source Homo sapiens (Human) (PHYL_DROME) Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC PGASCKWQGSLDAVMPHLMHQHKSICTLQGEDIVFLATDI NLPGAVDWVMMQSCFGFHFMLVLEKQEKQQFFAIVQLIGT RKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNS DCLVFDTSIAQLFAENGNLGINVTISMC Description Functional site 1) chain A residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 2) chain A residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 3) chain A residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 4) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 5) chain A residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 6) chain A residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 7) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 8) chain A residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 9) chain A residue 130 type sequence C description BINDING SITE FOR RESIDUE MPD A 603 source : AC3 10) chain A residue 131 type sequence P description BINDING SITE FOR RESIDUE MPD A 603 source : AC3 11) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE MPD A 603 source : AC3 12) chain A residue 154 type sequence S description BINDING SITE FOR RESIDUE MPD A 603 source : AC3 13) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE MPD A 603 source : AC3 14) chain A residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 15) chain A residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 16) chain A residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 17) chain A residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 18) chain A residue 93-153 type ZN_FING sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG ASCKWQGSLDAVMPHLMHQHK description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 20) chain A residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 21) chain A residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 22) chain A residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3

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