eF-site ID 4i7b-ABCD
PDB Code 4i7b
Chain A, B, C, D

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Title Siah1 bound to synthetic peptide (ACE)KLRPV(ABA)MVRPTVR
Classification LIGASE/LIGASE INHIBITOR
Compound E3 ubiquitin-protein ligase SIAH1
Source Homo sapiens (Human) (PHYL_DROME)
Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC
PGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDI
NLPGAVDWVMMQSCFGFHFMLVLEKQEGHQQFFAIVQLIG
TRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMN
SDCLVFDTSIAQLFAENGNLGINVTISMC
B:  LRPVXMVRPTV
C:  VLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGA
SCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLP
GAVDWVMMQSCFGFHFMLVLEKQEDGHQQFFAIVQLIGTR
KQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSD
CLVFDTSIAQLFAENGNLGINVTISMC
D:  LRPVXMVRPTV
Description


Functional site
1) chain A
residue 128
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
2) chain A
residue 135
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
3) chain A
residue 147
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
4) chain A
residue 152
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 601
source : AC1
5) chain A
residue 98
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
6) chain A
residue 105
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
7) chain A
residue 117
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
8) chain A
residue 121
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 602
source : AC2
9) chain C
residue 128
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 601
source : AC3
10) chain C
residue 135
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 601
source : AC3
11) chain C
residue 147
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 601
source : AC3
12) chain C
residue 152
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 601
source : AC3
13) chain C
residue 98
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 602
source : AC4
14) chain C
residue 105
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 602
source : AC4
15) chain C
residue 117
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 602
source : AC4
16) chain C
residue 121
type
sequence C
description BINDING SITE FOR RESIDUE ZN C 602
source : AC4
17) chain A
residue 156
type
sequence T
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
18) chain A
residue 158
type
sequence L
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
19) chain A
residue 162
type
sequence D
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
20) chain A
residue 163
type
sequence I
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
21) chain A
residue 164
type
sequence V
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
22) chain A
residue 165
type
sequence F
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
23) chain A
residue 166
type
sequence L
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
24) chain A
residue 168
type
sequence T
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
25) chain A
residue 175
type
sequence A
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
26) chain A
residue 176
type
sequence V
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
27) chain A
residue 177
type
sequence D
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
28) chain A
residue 178
type
sequence W
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
29) chain A
residue 179
type
sequence V
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
30) chain A
residue 180
type
sequence M
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
31) chain A
residue 276
type
sequence N
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
32) chain A
residue 278
type
sequence T
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
33) chain C
residue 268
type
sequence A
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
34) chain C
residue 269
type
sequence E
description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD
source : AC5
35) chain A
residue 230
type
sequence H
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
36) chain C
residue 156
type
sequence T
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
37) chain C
residue 158
type
sequence L
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
38) chain C
residue 162
type
sequence D
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
39) chain C
residue 163
type
sequence I
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
40) chain C
residue 164
type
sequence V
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
41) chain C
residue 165
type
sequence F
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
42) chain C
residue 166
type
sequence L
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
43) chain C
residue 168
type
sequence T
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
44) chain C
residue 176
type
sequence V
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
45) chain C
residue 177
type
sequence D
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
46) chain C
residue 178
type
sequence W
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
47) chain C
residue 179
type
sequence V
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
48) chain C
residue 180
type
sequence M
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
49) chain C
residue 276
type
sequence N
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
50) chain C
residue 282
type
sequence C
description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD
source : AC6
51) chain A
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
52) chain A
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
53) chain A
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
54) chain A
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
55) chain A
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
56) chain C
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
57) chain C
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
58) chain C
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
59) chain C
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
60) chain A
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
61) chain A
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
62) chain A
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
63) chain A
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
64) chain C
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
65) chain C
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
66) chain C
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
67) chain C
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3

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