eF-site ID 4i7b-A PDB Code 4i7b Chain A click to enlarge Title Siah1 bound to synthetic peptide (ACE)KLRPV(ABA)MVRPTVR Classification LIGASE/LIGASE INHIBITOR Compound E3 ubiquitin-protein ligase SIAH1 Source Homo sapiens (Human) (PHYL_DROME) Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC PGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDI NLPGAVDWVMMQSCFGFHFMLVLEKQEGHQQFFAIVQLIG TRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMN SDCLVFDTSIAQLFAENGNLGINVTISMC Description Functional site 1) chain A residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 2) chain A residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 3) chain A residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 4) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN A 601 source : AC1 5) chain A residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 6) chain A residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 7) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 8) chain A residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN A 602 source : AC2 9) chain A residue 156 type sequence T description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 10) chain A residue 158 type sequence L description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 11) chain A residue 162 type sequence D description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 12) chain A residue 163 type sequence I description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 13) chain A residue 164 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 14) chain A residue 165 type sequence F description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 15) chain A residue 166 type sequence L description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 16) chain A residue 168 type sequence T description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 17) chain A residue 175 type sequence A description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 18) chain A residue 176 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 19) chain A residue 177 type sequence D description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 20) chain A residue 178 type sequence W description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 21) chain A residue 179 type sequence V description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 22) chain A residue 180 type sequence M description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 23) chain A residue 276 type sequence N description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 24) chain A residue 278 type sequence T description BINDING SITE FOR CHAIN B OF PROTEIN PHYLLOPOD source : AC5 25) chain A residue 230 type sequence H description BINDING SITE FOR CHAIN D OF PROTEIN PHYLLOPOD source : AC6 26) chain A residue 93-153 type ZN_FING sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG ASCKWQGSLDAVMPHLMHQHK description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 28) chain A residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 29) chain A residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 30) chain A residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 31) chain A residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 32) chain A residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 33) chain A residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 34) chain A residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3

Display surface Download Links