eF-site ID 4i3s-GHL PDB Code 4i3s Chain G, H, L click to enlarge Title Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21 Classification Viral Protein/Immune System Compound Outer domain of HIV-1 gp120 (KER2018 OD4.2.2) Source (4I3S) Sequence G:  KPVVSTQLLLNGSLAEKEIRIKSEDISDNAKNIIVQLTKP VLINCARPSNNTQYCVVNRTQWNDTLGQVAIQLRKHWNTC IIFNEPSGGDLEITTHSFNCGGEFFYCNTSDLFNSTWNIE GTASIDDITLPCRIKGSGAPPIQGVIRCQSNITGILLTRD GGSGSGTCETFRPGGGDMRD H:  QVQLVQSGSGVKKPGASVRVSCWTSEDIFERTELIHWVRQ APGQGLEWIGWVKTVTGAVNFGSPDFRQRVSLTRDRDLFT AHMDIRGLTQGDTATYFCARQKFYTGGQGWYFDLWGRGTL IVVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVS WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT YICNVNHKPSNTKVDKKVEPKS L:  EIVLTQSPGTLSLSPGETASLSCTAASYGHMTWYQKKPGQ PPKLLIFATSKRASGIPDRFSGSQFGKQYTLTITRMEPED FARYYCQQLEFFGQGTRLEIRRTVAAPSVFIFPPSDEQLK SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQ DSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT KSFNRGEC Description Functional site 1) chain L residue 105 type sequence E description BINDING SITE FOR RESIDUE CA L 301 source : AC1 2) chain L residue 143 type sequence E description BINDING SITE FOR RESIDUE CA L 301 source : AC1 3) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290 4) chain L residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH source prosite : PS00290

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