eF-site ID 4i13-A PDB Code 4i13 Chain A click to enlarge Title Nanobody ca1697 binding to the DHFR.folate binary complex Classification OXIDOREDUCTASE/IMMUNE SYSTEM Compound Dihydrofolate reductase Source Escherichia coli (strain K12) (4I13) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description (1)  Dihydrofolate reductase (E.C.1.5.1.3), Protein ca1697 (nanobody) Functional site 1) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 2) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 3) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 4) chain A residue 27 type sequence D description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 5) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 6) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 7) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 8) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 9) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 10) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 11) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 12) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 13-35 type prosite sequence VIGMENAMPWNLPADLAWFKRNT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT source prosite : PS00075

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