eF-site ID 4hxd-ABCD PDB Code 4hxd Chain A, B, C, D Title Diversity of ubiquitin and ISG15 specificity amongst nairoviruses viral ovarian tumor domain proteases Classification hydrolase/viral protein Compound Polyubiquitin-C Source Homo sapiens (Human) (L_DUGBA) Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG B:  DFLDSLIWERVVDEQYITNPTFCVSDYFEVIRQPGDGNCF YHSIAELFFDVKTPSSFRKVKEHLQLAAEVYYDTEPEAVG TGISKDEYIKVAMKDNEWGGSLEASMLSKHLQTTIILWVV NSTEQVTAAIKFGPGRVSTALNLMHVGRTHFDALRII C:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG D:  FLDSLIWERVVDEQYITNPTFCVSDYFEVIRQPGDGNCFY HSIAELFFDVKTPSSFRKVKEHLQLAAEVYYDTEPEAVGT GISKDEYIKVAMKDNEWGGSLEASMLSKHLQTTIILWVVN STEQVTAAIKFGPGRVSTALNLMHVGRTHFDALRII Description Functional site 1) chain A residue 75 type sequence G description BINDING SITE FOR RESIDUE 4LJ A 101 source : AC1 2) chain B residue 38 type sequence G description BINDING SITE FOR RESIDUE 4LJ A 101 source : AC1 3) chain B residue 40 type sequence C description BINDING SITE FOR RESIDUE 4LJ A 101 source : AC1 4) chain B residue 99 type sequence W description BINDING SITE FOR RESIDUE 4LJ A 101 source : AC1 5) chain B residue 150 type sequence T description BINDING SITE FOR RESIDUE 4LJ A 101 source : AC1 6) chain A residue 9 type sequence T description BINDING SITE FOR RESIDUE SO4 A 102 source : AC2 7) chain A residue 11 type sequence K description BINDING SITE FOR RESIDUE SO4 A 102 source : AC2 8) chain B residue 91 type sequence K description BINDING SITE FOR RESIDUE SO4 A 102 source : AC2 9) chain B residue 123 type sequence S description BINDING SITE FOR RESIDUE SO4 A 102 source : AC2 10) chain C residue 75 type sequence G description BINDING SITE FOR RESIDUE 4LJ C 101 source : AC3 11) chain D residue 38 type sequence G description BINDING SITE FOR RESIDUE 4LJ C 101 source : AC3 12) chain D residue 40 type sequence C description BINDING SITE FOR RESIDUE 4LJ C 101 source : AC3 13) chain D residue 99 type sequence W description BINDING SITE FOR RESIDUE 4LJ C 101 source : AC3 14) chain D residue 150 type sequence T description BINDING SITE FOR RESIDUE 4LJ C 101 source : AC3 15) chain D residue 151 type sequence H description BINDING SITE FOR RESIDUE 4LJ C 101 source : AC3 16) chain C residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 C 102 source : AC4 17) chain D residue 98 type sequence E description BINDING SITE FOR RESIDUE SO4 C 102 source : AC4 18) chain D residue 99 type sequence W description BINDING SITE FOR RESIDUE SO4 C 102 source : AC4 19) chain C residue 9 type sequence T description BINDING SITE FOR RESIDUE SO4 D 201 source : AC5 20) chain C residue 11 type sequence K description BINDING SITE FOR RESIDUE SO4 D 201 source : AC5 21) chain D residue 91 type sequence K description BINDING SITE FOR RESIDUE SO4 D 201 source : AC5 22) chain D residue 123 type sequence S description BINDING SITE FOR RESIDUE SO4 D 201 source : AC5 23) chain A residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 24) chain C residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 25) chain A residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 26) chain C residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI10 28) chain C residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI10 29) chain A residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 30) chain C residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI5 32) chain C residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI5 33) chain A residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI6 34) chain C residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI6 35) chain C residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 36) chain C residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 37) chain A residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 38) chain A residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI7 39) chain D residue 151 type ACT_SITE sequence H description For ubiquitin thioesterase activity => ECO:0000250|UniProtKB:Q6TQR6 source Swiss-Prot : SWS_FT_FI1 40) chain D residue 153 type ACT_SITE sequence D description For ubiquitin thioesterase activity => ECO:0000250|UniProtKB:Q6TQR6 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 40 type ACT_SITE sequence C description For ubiquitin thioesterase activity => ECO:0000250|UniProtKB:Q6TQR6 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 153 type ACT_SITE sequence D description For ubiquitin thioesterase activity => ECO:0000250|UniProtKB:Q6TQR6 source Swiss-Prot : SWS_FT_FI1 43) chain D residue 40 type ACT_SITE sequence C description For ubiquitin thioesterase activity => ECO:0000250|UniProtKB:Q6TQR6 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 151 type ACT_SITE sequence H description For ubiquitin thioesterase activity => ECO:0000250|UniProtKB:Q6TQR6 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 46) chain B residue 76-94 type prosite sequence EPEAVGTGISKDEYIKVAM description TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EpeavgtGISKdeYIkvaM source prosite : PS00176 47) chain A residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI9 48) chain C residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI9 49) chain A residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI8 50) chain C residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI8

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