eF-site ID 4hw3-L PDB Code 4hw3 Chain L click to enlarge Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source Homo sapiens (Human) (MCL1_HUMAN) Sequence L:  GDELYRQSLEIISRYLREQATGKPMGRSGATSRKALETLR RVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVF SDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESI TDVLVRTKRDWLVKQRGWDGFVEFFHVED Description Functional site 1) chain L residue 246 type sequence L description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 2) chain L residue 250 type sequence M description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 3) chain L residue 253 type sequence V description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 4) chain L residue 263 type sequence R description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 5) chain L residue 266 type sequence T description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 6) chain L residue 267 type sequence L description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 7) chain L residue 270 type sequence F description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 8) chain L residue 271 type sequence G description BINDING SITE FOR RESIDUE 19G L 400 source : BC3 9) chain L residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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