eF-site ID 4hw3-I
PDB Code 4hw3
Chain I

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Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
Classification APOPTOSIS/INHIBITOR
Compound Induced myeloid leukemia cell differentiation protein Mcl-1
Source Homo sapiens (Human) (MCL1_HUMAN)
Sequence I:  GDELYRQSLEIISRYLREQATGAKDTKPSGATSRKALETL
RRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHV
FSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAES
ITDVLVRTKRDWLVKQRGWDGFVEFFH
Description


Functional site

1) chain I
residue 246
type
sequence L
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

2) chain I
residue 250
type
sequence M
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

3) chain I
residue 253
type
sequence V
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

4) chain I
residue 254
type
sequence F
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

5) chain I
residue 263
type
sequence R
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

6) chain I
residue 267
type
sequence L
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

7) chain I
residue 270
type
sequence F
description BINDING SITE FOR RESIDUE 19G I 400
source : AC9

8) chain I
residue 194
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

9) chain I
residue 197
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1


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