eF-site ID 4hw3-F PDB Code 4hw3 Chain F click to enlarge Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source Homo sapiens (Human) (MCL1_HUMAN) Sequence F:  GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL AESITDVLVRTKRDWLVKQRGWDGFVEFFHV Description Functional site 1) chain F residue 228 type sequence F description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 2) chain F residue 246 type sequence L description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 3) chain F residue 250 type sequence M description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 4) chain F residue 263 type sequence R description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 5) chain F residue 266 type sequence T description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 6) chain F residue 267 type sequence L description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 7) chain F residue 270 type sequence F description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 8) chain F residue 294 type sequence I description BINDING SITE FOR RESIDUE 19G F 400 source : AC6 9) chain F residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 10) chain F residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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