eF-site ID 4hw3-B PDB Code 4hw3 Chain B click to enlarge Title Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source Homo sapiens (Human) (MCL1_HUMAN) Sequence B:  GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL AESITDVLVRTKRDWLVKQRGWDGFVEFFHV Description Functional site 1) chain B residue 231 type sequence M description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 2) chain B residue 246 type sequence L description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 3) chain B residue 250 type sequence M description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 4) chain B residue 253 type sequence V description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 5) chain B residue 263 type sequence R description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 6) chain B residue 266 type sequence T description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 7) chain B residue 267 type sequence L description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 8) chain B residue 270 type sequence F description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 9) chain B residue 294 type sequence I description BINDING SITE FOR RESIDUE 19G B 400 source : AC2 10) chain B residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 11) chain B residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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