eF-site ID 4hna-ABDK PDB Code 4hna Chain A, B, D, K click to enlarge Title Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN Classification MOTOR PROTEIN Compound Tubulin alpha chain Source ORGANISM_COMMON: domestic sheep,lambs,wild sheep; ORGANISM_SCIENTIFIC: Ovis aries; Sequence A:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDD SFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLF HPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLAD QCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKL EFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNE AIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGA LNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLS VAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKD VNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGD LAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHW YVGEGMEEGEFSEAREDMAALEKDYEEVGV B:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY SIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGR MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG EGMDEMEFTEAESNMNDLVSEYQQYQDATAD D:  GSDLGKKLLEAARAGQDDEVRILMANGADVNAEDDSGKTP LHLAAIKGHLEIVEVLLKHGADVNAADKMGDTPLHLAALY GHLEIVEVLLKNGADVNATDTYGFTPLHLAADAGHLEIVE VLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLN K:  AESNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASK PYAFDRVFQSSTSQEQVYNDAAKKIVKDVLEGYNGTIFAY GQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDE NLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPY VKGATERFVSSPDEVMDTIDEGKSNRHVAVTNMNEHSSRS HSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAE GAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTR ILQDSLGGNARTTIVICCSPSSYNESETKSTLLFGQRAKT IKNTVSVNVELTA Description Functional site 1) chain A residue 10 type sequence G description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 2) chain A residue 11 type sequence Q description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 3) chain A residue 12 type sequence A description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 4) chain A residue 15 type sequence Q description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 5) chain A residue 69 type sequence D description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 6) chain A residue 98 type sequence D description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 7) chain A residue 99 type sequence A description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 8) chain A residue 100 type sequence A description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 9) chain A residue 101 type sequence N description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 10) chain A residue 140 type sequence S description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 11) chain A residue 143 type sequence G description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 12) chain A residue 144 type sequence G description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 13) chain A residue 145 type sequence T description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 14) chain A residue 146 type sequence G description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 15) chain A residue 177 type sequence V description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 16) chain A residue 183 type sequence E description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 17) chain A residue 206 type sequence N description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 18) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 19) chain A residue 228 type sequence N description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 20) chain A residue 231 type sequence I description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 21) chain B residue 254 type sequence K description BINDING SITE FOR RESIDUE GTP A 600 source : AC1 22) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 23) chain B residue 11 type sequence Q description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 24) chain B residue 12 type sequence C description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 25) chain B residue 15 type sequence Q description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 26) chain B residue 140 type sequence S description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 27) chain B residue 143 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 28) chain B residue 144 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 29) chain B residue 145 type sequence T description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 30) chain B residue 146 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 31) chain B residue 177 type sequence V description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 32) chain B residue 178 type sequence S description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 33) chain B residue 183 type sequence E description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 34) chain B residue 206 type sequence N description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 35) chain B residue 224 type sequence Y description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 36) chain B residue 228 type sequence N description BINDING SITE FOR RESIDUE GDP B 501 source : AC3 37) chain B residue 11 type sequence Q description BINDING SITE FOR RESIDUE MG B 502 source : AC4 38) chain B residue 71 type sequence E description BINDING SITE FOR RESIDUE MG B 502 source : AC4 39) chain B residue 71 type sequence E description BINDING SITE FOR RESIDUE ALF B 503 source : AC5 40) chain B residue 99 type sequence A description BINDING SITE FOR RESIDUE ALF B 503 source : AC5 41) chain B residue 100 type sequence G description BINDING SITE FOR RESIDUE ALF B 503 source : AC5 42) chain B residue 101 type sequence N description BINDING SITE FOR RESIDUE ALF B 503 source : AC5 43) chain B residue 144 type sequence G description BINDING SITE FOR RESIDUE ALF B 503 source : AC5 44) chain B residue 145 type sequence T description BINDING SITE FOR RESIDUE ALF B 503 source : AC5 45) chain D residue 101 type sequence K description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 46) chain K residue 14 type sequence R description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 47) chain K residue 16 type sequence R description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 48) chain K residue 17 type sequence P description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 49) chain K residue 88 type sequence S description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 50) chain K residue 89 type sequence S description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 51) chain K residue 90 type sequence G description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 52) chain K residue 91 type sequence K description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 53) chain K residue 92 type sequence T description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 54) chain K residue 93 type sequence H description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 55) chain K residue 198 type sequence N description BINDING SITE FOR RESIDUE ADP K 401 source : AC6 56) chain K residue 92 type sequence T description BINDING SITE FOR RESIDUE MG K 402 source : AC7 57) chain K residue 202 type sequence S description BINDING SITE FOR RESIDUE MG K 402 source : AC7 58) chain K residue 87 type sequence T description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 59) chain K residue 88 type sequence S description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 60) chain K residue 91 type sequence K description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 61) chain K residue 198 type sequence N description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 62) chain K residue 201 type sequence S description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 63) chain K residue 202 type sequence S description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 64) chain K residue 233 type sequence A description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 65) chain K residue 234 type sequence G description BINDING SITE FOR RESIDUE ALF K 403 source : AC8 66) chain K residue 213 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI3 67) chain A residue 142-148 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 68) chain B residue 142-148 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 69) chain B residue 1-4 type prosite sequence MREI description TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI source prosite : PS00228 70) chain K residue 225-236 type prosite sequence GKLYLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLyLVDLAGSE source prosite : PS00411 71) chain K residue 85 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1

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