eF-site ID 4hls-AB PDB Code 4hls Chain A, B click to enlarge Title Crystal structure of mutant rabbit PRP 121-230 (S170N) Classification MEMBRANE PROTEIN Compound Major prion protein Source Oryctolagus cuniculus (Rabbit) (PRIO_RABIT) Sequence A:  GGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRP VDQYNNQNSFVHDCVNITVKQHTVTTTTKGENFTETDIKI MERVVEQMCITQYQQES B:  GGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRP VDQYNNQNSFVHDCVNITVKQHTVTTTTKGENFTETDIKI MERVVEQMCITQYQQESQAAYQRAA Description Functional site 1) chain A residue 136 type sequence R description BINDING SITE FOR RESIDUE CL A 301 source : AC1 2) chain A residue 148 type sequence R description BINDING SITE FOR RESIDUE CL A 301 source : AC1 3) chain A residue 142 type sequence G description BINDING SITE FOR RESIDUE NA A 302 source : AC2 4) chain A residue 144 type sequence D description BINDING SITE FOR RESIDUE NA A 302 source : AC2 5) chain A residue 152 type sequence E description BINDING SITE FOR RESIDUE NA A 302 source : AC2 6) chain A residue 192 type sequence T description BINDING SITE FOR RESIDUE NA A 303 source : AC3 7) chain A residue 196 type sequence E description BINDING SITE FOR RESIDUE NA A 303 source : AC3 8) chain A residue 197 type sequence N description BINDING SITE FOR RESIDUE NA A 303 source : AC3 9) chain B residue 192 type sequence T description BINDING SITE FOR RESIDUE NA A 303 source : AC3 10) chain B residue 196 type sequence E description BINDING SITE FOR RESIDUE NA A 303 source : AC3 11) chain B residue 197 type sequence N description BINDING SITE FOR RESIDUE NA A 303 source : AC3 12) chain B residue 136 type sequence R description BINDING SITE FOR RESIDUE CL B 301 source : AC4 13) chain B residue 148 type sequence R description BINDING SITE FOR RESIDUE CL B 301 source : AC4 14) chain B residue 142 type sequence G description BINDING SITE FOR RESIDUE NA B 302 source : AC5 15) chain B residue 144 type sequence D description BINDING SITE FOR RESIDUE NA B 302 source : AC5 16) chain B residue 152 type sequence E description BINDING SITE FOR RESIDUE NA B 302 source : AC5 17) chain B residue 131 type sequence G description BINDING SITE FOR RESIDUE NA B 303 source : AC6 18) chain B residue 132 type sequence S description BINDING SITE FOR RESIDUE NA B 303 source : AC6 19) chain B residue 134 type sequence M description BINDING SITE FOR RESIDUE NA B 303 source : AC6 20) chain B residue 160 type sequence Q description BINDING SITE FOR RESIDUE NA B 303 source : AC6 21) chain B residue 161 type sequence V description BINDING SITE FOR RESIDUE NA B 303 source : AC6 22) chain B residue 217 type sequence Q description BINDING SITE FOR RESIDUE NA B 303 source : AC6 23) chain B residue 228 type sequence R description BINDING SITE FOR RESIDUE NA B 304 source : AC7 24) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE NA B 305 source : AC8 25) chain A residue 149 type sequence Y description BINDING SITE FOR RESIDUE NA B 305 source : AC8 26) chain A residue 201 type sequence T description BINDING SITE FOR RESIDUE NA B 305 source : AC8 27) chain B residue 230 type sequence A description BINDING SITE FOR RESIDUE NA B 305 source : AC8 28) chain A residue 177 type sequence H description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 29) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 30) chain A residue 181 type sequence N description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 31) chain B residue 128 type sequence Y description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 32) chain B residue 164 type sequence R description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 33) chain B residue 178 type sequence D description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 34) chain B residue 181 type sequence N description BINDING SITE FOR RESIDUE GOL B 306 source : AC9 35) chain B residue 138 type sequence L description BINDING SITE FOR RESIDUE GOL B 307 source : BC1 36) chain B residue 139 type sequence I description BINDING SITE FOR RESIDUE GOL B 307 source : BC1 37) chain B residue 147 type sequence D description BINDING SITE FOR RESIDUE GOL B 307 source : BC1 38) chain B residue 150 type sequence Y description BINDING SITE FOR RESIDUE GOL B 307 source : BC1 39) chain B residue 151 type sequence R description BINDING SITE FOR RESIDUE GOL B 307 source : BC1 40) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE GOL B 308 source : BC2 41) chain A residue 151 type sequence R description BINDING SITE FOR RESIDUE GOL B 308 source : BC2 42) chain B residue 226 type sequence Y description BINDING SITE FOR RESIDUE GOL B 308 source : BC2 43) chain B residue 229 type sequence A description BINDING SITE FOR RESIDUE GOL B 308 source : BC2 44) chain B residue 230 type sequence A description BINDING SITE FOR RESIDUE GOL B 308 source : BC2 45) chain A residue 200-218 type prosite sequence ETDIKIMERVVEQMCITQY description PRION_2 Prion protein signature 2. EtDiKIMeRVVeQMCitQY source prosite : PS00706 46) chain B residue 230 type LIPID sequence A description GPI-anchor amidated alanine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 181 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 197 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 181 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 197 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2

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