eF-site ID 4hlm-ABCD PDB Code 4hlm Chain A, B, C, D click to enlarge Title Crystal structure of Tankyrase 2 in complex with 3',4'-Dihydroxyflavone Classification TRANSFERASE Compound Tankyrase-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS A B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AM C:  MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLIT YQIMRPE D:  MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLIT YQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 1201 source : AC1 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 1201 source : AC1 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 1201 source : AC1 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 1201 source : AC1 5) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1202 source : AC2 6) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1202 source : AC2 7) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1202 source : AC2 8) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1202 source : AC2 9) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1202 source : AC2 10) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 11) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 12) chain C residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 13) chain C residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 14) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 15) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 16) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 17) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 18) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 19) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 20) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 21) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 22) chain A residue 1075 type sequence I description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 23) chain C residue 1138 type sequence E description BINDING SITE FOR RESIDUE 16S A 1204 source : AC4 24) chain C residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL C 1201 source : AC5 25) chain C residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL C 1201 source : AC5 26) chain C residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL C 1201 source : AC5 27) chain C residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL C 1201 source : AC5 28) chain C residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL C 1201 source : AC5 29) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 1201 source : AC6 30) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 1201 source : AC6 31) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 1201 source : AC6 32) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 1201 source : AC6 33) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1202 source : AC7 34) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1202 source : AC7 35) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1202 source : AC7 36) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1202 source : AC7 37) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1202 source : AC7 38) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1203 source : AC8 39) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1203 source : AC8 40) chain D residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1203 source : AC8 41) chain D residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1203 source : AC8 42) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 43) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 44) chain B residue 1033 type sequence S description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 45) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 46) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 47) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 48) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 49) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 50) chain D residue 1138 type sequence E description BINDING SITE FOR RESIDUE 16S B 1204 source : AC9 51) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 57) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 58) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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