eF-site/Summary 4hkc-AB

eF-site ID	4hkc-AB
PDB Code	4hkc
Chain	A, B

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Title	14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
Classification	SIGNALING PROTEIN/PEPTIDE
Compound	14-3-3 protein zeta/delta
Source	Homo sapiens (Human) (ITA4_HUMAN)

Sequence	A:	DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEER NLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMARE YREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKM KGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQ PTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIA ELDTLSEESYKDSTLIMQLLRDNLTLWTS
	B:	KRQYKXIL

Description

Functional site


1)	chain	A
	residue	203
	type
	sequence	L
	description	BINDING SITE FOR RESIDUE GOL A 301
	source	: AC1

2)	chain	A
	residue	204
	type
	sequence	D
	description	BINDING SITE FOR RESIDUE GOL A 301
	source	: AC1

3)	chain	A
	residue	206
	type
	sequence	L
	description	BINDING SITE FOR RESIDUE GOL A 301
	source	: AC1

4)	chain	A
	residue	3
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI3

5)	chain	A
	residue	68
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI3

6)	chain	A
	residue	58
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269\|PubMed:11956222, ECO:0000269\|PubMed:12865427, ECO:0000269\|PubMed:15883165, ECO:0000269\|PubMed:16376338
	source	Swiss-Prot : SWS_FT_FI4

7)	chain	A
	residue	184
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:15071501, ECO:0000269\|PubMed:15696159
	source	Swiss-Prot : SWS_FT_FI5

8)	chain	A
	residue	207
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231
	source	Swiss-Prot : SWS_FT_FI6

9)	chain	A
	residue	210
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000250\|UniProtKB:P63102
	source	Swiss-Prot : SWS_FT_FI7

10)	chain	A
	residue	127
	type	MOD_RES
	sequence	R
	description	Phosphoserine => ECO:0000269\|PubMed:11533025, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:24275569
	source	Swiss-Prot : SWS_FT_FI1

11)	chain	A
	residue	41-51
	type	prosite
	sequence	RNLLSVAYKNV
	description	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
	source	prosite : PS00796

12)	chain	A
	residue	211-230
	type	prosite
	sequence	YKDSTLIMQLLRDNLTLWTS
	description	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
	source	prosite : PS00797