eF-site/Summary 4hje-A

eF-site ID	4hje-A
PDB Code	4hje
Chain	A

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Title	Crystal structure of p53 core domain in complex with DNA
Classification	Transcription/DNA
Compound	Cellular tumor antigen p53
Source	Homo sapiens (Human) (4HJE)

Sequence	A:	PLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALN KMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTE VVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNT FRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPI LTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRK

Description

Functional site


1)	chain	A
	residue	176
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 301
	source	: AC1

2)	chain	A
	residue	179
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE ZN A 301
	source	: AC1

3)	chain	A
	residue	238
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 301
	source	: AC1

4)	chain	A
	residue	242
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 301
	source	: AC1

5)	chain	A
	residue	176
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000269\|PubMed:14534297, ECO:0000269\|PubMed:16793544, ECO:0000269\|PubMed:17015838, ECO:0000269\|PubMed:18650397, ECO:0000269\|PubMed:19515728, ECO:0000269\|PubMed:20142040, ECO:0000269\|PubMed:20364130
	source	Swiss-Prot : SWS_FT_FI1

6)	chain	A
	residue	179
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:14534297, ECO:0000269\|PubMed:16793544, ECO:0000269\|PubMed:17015838, ECO:0000269\|PubMed:18650397, ECO:0000269\|PubMed:19515728, ECO:0000269\|PubMed:20142040, ECO:0000269\|PubMed:20364130
	source	Swiss-Prot : SWS_FT_FI1

7)	chain	A
	residue	238
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000269\|PubMed:14534297, ECO:0000269\|PubMed:16793544, ECO:0000269\|PubMed:17015838, ECO:0000269\|PubMed:18650397, ECO:0000269\|PubMed:19515728, ECO:0000269\|PubMed:20142040, ECO:0000269\|PubMed:20364130
	source	Swiss-Prot : SWS_FT_FI1

8)	chain	A
	residue	242
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000269\|PubMed:14534297, ECO:0000269\|PubMed:16793544, ECO:0000269\|PubMed:17015838, ECO:0000269\|PubMed:18650397, ECO:0000269\|PubMed:19515728, ECO:0000269\|PubMed:20142040, ECO:0000269\|PubMed:20364130
	source	Swiss-Prot : SWS_FT_FI1

9)	chain	A
	residue	120
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine; by KAT6A => ECO:0000269\|PubMed:23431171
	source	Swiss-Prot : SWS_FT_FI3

10)	chain	A
	residue	120
	type	SITE
	sequence	K
	description	Interaction with DNA => ECO:0000269\|PubMed:16793544, ECO:0000269\|PubMed:18996393, ECO:0000269\|PubMed:20364130
	source	Swiss-Prot : SWS_FT_FI2

11)	chain	A
	residue	183
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by AURKB => ECO:0000269\|PubMed:20959462
	source	Swiss-Prot : SWS_FT_FI4

12)	chain	A
	residue	269
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by AURKB => ECO:0000269\|PubMed:20959462
	source	Swiss-Prot : SWS_FT_FI4

13)	chain	A
	residue	284
	type	MOD_RES
	sequence	T
	description	Phosphothreonine; by AURKB => ECO:0000269\|PubMed:20959462
	source	Swiss-Prot : SWS_FT_FI5

14)	chain	A
	residue	291
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:19536131
	source	Swiss-Prot : SWS_FT_FI6

15)	chain	A
	residue	237-249
	type	prosite
	sequence	MCNSSCMGGMNRR
	description	P53 p53 family signature. MCNSSCMGGMNRR
	source	prosite : PS00348