eF-site ID 4hcc-ABCD PDB Code 4hcc Chain A, B, C, D click to enlarge Title The zinc ion bound form of crystal structure of E.coli ExoI-ssDNA complex Classification HYDROLASE/DNA Compound Exodeoxyribonuclease I Source Escherichia coli (strain K12) (4HCC) Sequence A:  QQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEP EVFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAA RIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAW SWQHDNSRWDLLDVMRACYALRPEGINWPENLPSFRLEHL TKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDYLF THRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPL AWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTD LGDNAAVPVKLVHINKCPVLAQANTLRPEDADRLGINRQH CLDNLKILRENPQVREKVVAIFAEPFTPSDNVDAQLYNGF FSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYR ARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLV QQYADDKEKVALLKALWQYADEIVH B:  QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPE VFYCKPADDYLPQPGAVLITGITPQEARAKGENEAAFAAR IHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNFYDPYAWS WQHDNSRWDLLDVMRACYALRPEGINWPENLPSFRLEHLT KANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDYLFT HRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLA WHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDL GDNAAVPVKLVHINKCPVLAQANTLRPEDADRLGINRQHC LDNLKILRENPQVREKVVAIFAEFTPSDNVDAQLYNGFFS DADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRAR NFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQ YADDKEKVALLKALWQYADEIVH C:  AAAAAAAAAA D:  AAAAAAAAAA Description Functional site 1) chain A residue 414 type sequence N description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 2) chain A residue 415 type sequence F description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 3) chain A residue 416 type sequence P description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 4) chain A residue 417 type sequence G description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 5) chain A residue 106 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 6) chain A residue 235 type sequence M description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 7) chain A residue 299 type sequence K description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 8) chain A residue 419 type sequence L description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 9) chain A residue 420 type sequence D description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 10) chain A residue 421 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 11) chain B residue 178 type sequence S description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 12) chain B residue 179 type sequence N description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 13) chain A residue 15 type sequence D description BINDING SITE FOR RESIDUE ZN A 504 source : AC4 14) chain A residue 17 type sequence E description BINDING SITE FOR RESIDUE ZN A 504 source : AC4 15) chain A residue 186 type sequence D description BINDING SITE FOR RESIDUE ZN A 504 source : AC4 16) chain A residue 17 type sequence E description BINDING SITE FOR RESIDUE IPA A 505 source : AC5 17) chain A residue 18 type sequence T description BINDING SITE FOR RESIDUE IPA A 505 source : AC5 18) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC6 19) chain A residue 215 type sequence H description BINDING SITE FOR RESIDUE SO4 B 501 source : AC6 20) chain A residue 256 type sequence R description BINDING SITE FOR RESIDUE SO4 B 501 source : AC6 21) chain B residue 214 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC6 22) chain B residue 215 type sequence H description BINDING SITE FOR RESIDUE SO4 B 501 source : AC6 23) chain B residue 256 type sequence R description BINDING SITE FOR RESIDUE SO4 B 501 source : AC6 24) chain A residue 430 type sequence H description BINDING SITE FOR RESIDUE SO4 B 502 source : AC7 25) chain A residue 433 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 502 source : AC7 26) chain A residue 434 type sequence V description BINDING SITE FOR RESIDUE SO4 B 502 source : AC7 27) chain B residue 438 type sequence E description BINDING SITE FOR RESIDUE SO4 B 502 source : AC7 28) chain B residue 106 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 29) chain B residue 233 type sequence S description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 30) chain B residue 235 type sequence M description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 31) chain B residue 299 type sequence K description BINDING SITE FOR RESIDUE SO4 B 503 source : AC8 32) chain A residue 332 type sequence D description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 33) chain B residue 11 type sequence F description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 34) chain B residue 198 type sequence K description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 35) chain B residue 205 type sequence F description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 36) chain B residue 206 type sequence D description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 37) chain B residue 209 type sequence F description BINDING SITE FOR RESIDUE SO4 B 504 source : AC9 38) chain B residue 15 type sequence D description BINDING SITE FOR RESIDUE ZN B 505 source : BC1 39) chain B residue 17 type sequence E description BINDING SITE FOR RESIDUE ZN B 505 source : BC1 40) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE ZN B 505 source : BC1 41) chain A residue 442 type sequence G description BINDING SITE FOR RESIDUE IPA B 506 source : BC2 42) chain A residue 443 type sequence Y description BINDING SITE FOR RESIDUE IPA B 506 source : BC2 43) chain A residue 446 type sequence E description BINDING SITE FOR RESIDUE IPA B 506 source : BC2 44) chain B residue 446 type sequence E description BINDING SITE FOR RESIDUE IPA B 506 source : BC2 45) chain B residue 18 type sequence T description BINDING SITE FOR RESIDUE IPA B 507 source : BC3 46) chain A residue 15 type sequence D description BINDING SITE FOR RESIDUE PO4 C 101 source : BC4 47) chain A residue 17 type sequence E description BINDING SITE FOR RESIDUE PO4 C 101 source : BC4 48) chain A residue 181 type sequence H description BINDING SITE FOR RESIDUE PO4 C 101 source : BC4 49) chain A residue 186 type sequence D description BINDING SITE FOR RESIDUE PO4 C 101 source : BC4 50) chain C residue 12 type sequence A description BINDING SITE FOR RESIDUE PO4 C 101 source : BC4 51) chain B residue 15 type sequence D description BINDING SITE FOR RESIDUE PO4 D 101 source : BC5 52) chain B residue 17 type sequence E description BINDING SITE FOR RESIDUE PO4 D 101 source : BC5 53) chain B residue 181 type sequence H description BINDING SITE FOR RESIDUE PO4 D 101 source : BC5 54) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE PO4 D 101 source : BC5 55) chain D residue 12 type sequence A description BINDING SITE FOR RESIDUE PO4 D 101 source : BC5 56) chain A residue 338 type SITE sequence R description Important for interaction with ssb => ECO:0000305|PubMed:20018747 source Swiss-Prot : SWS_FT_FI7 57) chain B residue 338 type SITE sequence R description Important for interaction with ssb => ECO:0000305|PubMed:20018747 source Swiss-Prot : SWS_FT_FI7 58) chain A residue 15 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI1 59) chain B residue 15 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 17 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 61) chain B residue 165 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 186 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 63) chain A residue 165 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 186 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 17 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18219121 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 371 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 67) chain B residue 18 type SITE sequence T description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 68) chain B residue 66 type SITE sequence I description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 69) chain B residue 113 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 70) chain B residue 124 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 71) chain B residue 128 type SITE sequence W description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 142 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 73) chain B residue 214 type SITE sequence K description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 74) chain B residue 284 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 75) chain B residue 368 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 76) chain B residue 371 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 77) chain A residue 128 type SITE sequence W description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 78) chain A residue 142 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 79) chain A residue 214 type SITE sequence K description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 80) chain A residue 284 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 81) chain A residue 368 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 82) chain A residue 18 type SITE sequence T description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 83) chain A residue 66 type SITE sequence I description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 84) chain A residue 113 type SITE sequence R description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 85) chain A residue 124 type SITE sequence Y description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI3 86) chain A residue 148 type SITE sequence R description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 87) chain A residue 207 type SITE sequence Y description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 88) chain A residue 311 type SITE sequence Q description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 89) chain B residue 148 type SITE sequence R description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 90) chain B residue 207 type SITE sequence Y description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 91) chain B residue 311 type SITE sequence Q description Important for interaction with ssb => ECO:0000269|PubMed:18591666 source Swiss-Prot : SWS_FT_FI4 92) chain B residue 164 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 93) chain B residue 257 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 94) chain B residue 304 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 95) chain A residue 164 type SITE sequence F description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 96) chain A residue 257 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 97) chain A residue 304 type SITE sequence N description Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC source Swiss-Prot : SWS_FT_FI5 98) chain A residue 181 type SITE sequence H description Important for activity => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI6 99) chain B residue 181 type SITE sequence H description Important for activity => ECO:0000269|PubMed:23609540 source Swiss-Prot : SWS_FT_FI6

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